Molecular Basis of PAC1R Allosteric Modulation with Lipids in Membranes
Nicholas B. Hamilton, Bo Yang, Chijian Xiang, Tongtong Li, Severin T. Schneebeli, Jianing Li
This study identifies lipid binding sites on PAC1R using simulations, showing cholesterol and GM3 interact with the receptor in multiple domains, potentially influencing its activation.
bioRxiv · Jan 27, 2025 · PreprintBiophysics