Severin T. Schneebeli

A multiscale modeling framework for transport of PEGylated lipid nanoparticle through the extracellular matrix

This paper develops a multiscale computational framework to model PEGylated lipid nanoparticle transport through the extracellular matrix, showing that even low PEG density significantly enhances diffusivity.

Progressive Backmapping of Highly Coarse-Grained Protein Models

This paper introduces a progressive backmapping framework to reconstruct all-atom protein structures from highly coarse-grained models, achieving high accuracy across multiple resolutions and complex assemblies.

Molecular Basis of PAC1R Allosteric Modulation with Lipids in Membranes

This study identifies lipid binding sites on PAC1R using simulations, showing cholesterol and GM3 interact with the receptor in multiple domains, potentially influencing its activation.