The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR
Kenneth P. Callahan, Aisharja Mojumdar, Mengzhou Hu, Amber W. Wang, Alijah A. Griffith, Nicholas Huang, Xien Yu Chua, Nick Mroz, Ryan Z Puterbaugh, Shanelle P. Reilly, Arthur R. Salomon
This study investigates the roles of TCPTP, PTPN22, and SHP1 in T cell phosphotyrosine regulation and TCR signaling using CRISPR/Cas9 and mass spectrometry, revealing distinct effects on pY levels and Erk1/2 feedback.
Scientific Reports · Jul 30, 2025Peer-reviewedSystems Biology