Arthur R. Salomon

CSF1R-CAR T cells induce CSF1R signaling in THP1 cells, promoting their growth, highlighting an unintended effect of CAR therapy.

The paper evaluates the effects of Zap70 and Itk inhibitors on T cell activation and identifies novel phosphotyrosine targets using proteomics.

This study investigates the roles of TCPTP, PTPN22, and SHP1 in T cell phosphotyrosine regulation and TCR signaling using CRISPR/Cas9 and mass spectrometry, revealing distinct effects on pY levels and Erk1/2 feedback.

This study investigates how the inclusion of the ζ-chain affects phosphotyrosine signaling in CD19-CAR T cells using phosphoproteomics and inhibitor experiments.

The paper evaluates desalting techniques for phosphoproteomics, finding ProtiFi S-Trap to be most effective for peptide sequencing and phosphotyrosine site identification.