Integrative proteomic analysis and molecular dynamics simulations of ANKLE2 reveal mechanisms of microcephaly
Adam T. Fishburn, Vardhan Peddamallu, Nicholas J. Lopez, Ines M. Bilkic, Isabella J Hixson, Edwina Mambou, Heng Pan, Boris Bonaventure, Cole J. Florio, Chase L. S. Skawinski, Michelle Lopez Ramos, Parth R Bandivadekar, Sydney S. Becker, Bhargavi Gidugu, Judith L.A. Fishburn, , Priya S. Shah
The paper uses proteomic analysis and molecular dynamics simulations to uncover how ANKLE2 mutations disrupt protein interactions and phosphorylation, leading to microcephaly.
bioRxiv · Sep 29, 2026 · PreprintSystems Biology