Boris Bonaventure

The paper uses proteomic analysis and molecular dynamics simulations to uncover how ANKLE2 mutations disrupt protein interactions and phosphorylation, leading to microcephaly.

This study identifies USP7 as a gene that restricts neurotropic orthoflavivirus entry by controlling endosomal dynamics, with mutations in USP7 increasing susceptibility to ZIKV infection.

This study identifies the nuclear localization and interactome of TBEV NS5 protein, revealing its role in modulating viral replication through interactions with nuclear factors.

This study shows SARS-CoV-2 hijacks Golgi-bound PI4P via OSBP1, leading to cytoplasmic ATM activation and impaired viral replication with ATM inhibitors.

This study identifies key residues in the CHIKV nsP4 polymerase palm and ring finger domains that influence replication, genetic stability, and assembly across different hosts.