Priya S. Shah

The paper uses proteomic analysis and molecular dynamics simulations to uncover how ANKLE2 mutations disrupt protein interactions and phosphorylation, leading to microcephaly.

The paper predicts ACE2 receptor binding potential of emerging betacoronaviruses using structural prediction and molecular dynamics, identifying Zhejiang2013 as a potential ACE2 binder.

The paper uses sequence and structural alignments to study ANKLE2 evolution and function, revealing conserved domains and potential roles in DNA damage response.

The paper identifies CHD8 interactions in mouse brain, revealing a role in chromatin-associated RNA processing and highlighting dosage sensitivity in neurodevelopmental disorders.

The paper develops an image-based pipeline to analyze autophagy changes in ZIKV-infected cells and trains a deep learning classifier to identify infected cells using autophagy reporters.

This study shows that the filamentous fungus Thermothelomyces heterothallica C1 can produce thermostable SARS-CoV-2 spike protein with a human-like glycan profile, comparable to mammalian systems.

This paper simplifies the LACE optogenetic system from four to two plasmids, showing similar performance with reduced variability.

The paper maps YFV interactomes in human and mosquito cells, identifies RBBP6 as a restriction factor, and reveals divergent host interaction strategies among flaviviruses.

This study develops an image-based profiling approach to characterize autophagy-related phenotypes with high temporal resolution and identifies key morphological features for drug response prediction.

This study uses Drosophila to express Zika virus proteins and identifies phenotypes and host pathways disrupted by the virus during development.

The paper identifies PAF1's role in both activating and repressing immune-related gene expression through transcriptomic analysis and computational modeling.

This paper develops a framework to measure autophagy rates under non-steady state conditions and applies it to study temporal responses to rapamycin and wortmannin treatments.

This paper investigates how ZIKV NS4A interacts with host ANKLE2 to promote viral replication and disrupt neurodevelopment.