Heng Pan

The paper uses proteomic analysis and molecular dynamics simulations to uncover how ANKLE2 mutations disrupt protein interactions and phosphorylation, leading to microcephaly.

This study identifies USP7 as a gene that restricts neurotropic orthoflavivirus entry by controlling endosomal dynamics, with mutations in USP7 increasing susceptibility to ZIKV infection.

This study identifies the nuclear localization and interactome of TBEV NS5 protein, revealing its role in modulating viral replication through interactions with nuclear factors.

The paper introduces an inverse Transwell assay to study mucus barrier function against respiratory viruses and identifies MUC5AC's role in antiviral defense.

The paper identifies glypican-1 (GPC1) as a novel modulator of HIV-1 infection, showing its upregulation by a kinase inhibitor enhances viral infection through TGF-β signaling.