tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast
Joana F Tavares, Nick Davis, Ana Poim, Andreia Reis, Stefanie M. Kellner, Inês Sousa, Ana Raquel Soares, Gabriela Moura, Peter C. Dedon, Manuel A. S. Santos
The paper shows that mutations in tRNA-modifying enzymes in yeast lead to mistranslation and protein aggregation by affecting specific tRNA modifications.
RNA Biology · Sep 6, 2020Peer-reviewedMolecular Biology