Inhibition of Bruton’s tyrosine kinase reduces NF-kB and NLRP3 inflammasome activity preventing insulin resistance and microvascular disease
Gareth S. D. Purvis, Massimo Collino, Haidée Aranda-Tavío, Fausto Chiazza, Caroline E. O’Riodan, Lynda Zeboudj, Nick Guisot, Peter Bunyard, David R. Greaves, Christoph Thiemermann
This study shows that inhibiting BTK with ibrutinib reduces inflammation and prevents insulin resistance and microvascular disease in mice and human macrophages.
bioRxiv · Aug 28, 2019 · PreprintSystems Biology