Author

Gareth S. D. Purvis

University of OxfordORCID 0000-0003-4118-1568Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

David R. GreavesiD· 2 shared Gillian DouglasiD· 2 shared Keith M. ChannoniD· 2 shared Adam J. MeadiD· 1 shared Albert HenryiD· 1 shared Andy TraniD· 1 shared Carmen Mifsud· 1 shared Caroline E. O’Riodan· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

David R. GreavesORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 15, 2025

Hypercholesterolaemia promotes epigenetic memory in hematopoietic stem cells that persists after lipid lowering and causes systemic immunometabolic dysfunction mediated by macrophage metabolic reprogramming

Gareth S. D. Purvis, Jiahao Jiang, Thomas K. Hiron…·Keith M. Channon

This study shows that high cholesterol induces epigenetic changes in hematopoietic stem cells that persist after cholesterol reduction, leading to systemic immunometabolic dysfunction.

2 citations

mousebulk RNA-seq

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Cell BiologybioRxivPreprintAug 18, 2025

Endothelial Colony-Forming Cell Transcriptomic Profiling in CT-defined Coronary Artery Disease from the BioHEART-CT Study Implicate CCBE1 in Mitochondrial Dysfunction-associated Atherosclerosis

Weiqian Eugene Lee, Sarah L. Cook, Gareth S. D. Purvis…·Gemma Alexandra Figtree

This study identifies CCBE1 as a gene associated with mitochondrial dysfunction in atherosclerosis using transcriptomic analysis of endothelial cells from CAD patients.

1 citation

humanbulk RNA-seq

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Systems BiologybioRxivPreprintAug 28, 2019

Inhibition of Bruton’s tyrosine kinase reduces NF-kB and NLRP3 inflammasome activity preventing insulin resistance and microvascular disease

Gareth S. D. Purvis, Massimo Collino, Haidée Aranda-Tavío…·Christoph Thiemermann

This study shows that inhibiting BTK with ibrutinib reduces inflammation and prevents insulin resistance and microvascular disease in mice and human macrophages.

3 citations

mousehuman

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