Systems BiologybioRxivPreprint
Inhibition of Bruton’s tyrosine kinase reduces NF-kB and NLRP3 inflammasome activity preventing insulin resistance and microvascular disease
Gareth S. D. Purvis, Massimo Collino, Haidée Aranda-Tavío…·Christoph Thiemermann
This study shows that inhibiting BTK with ibrutinib reduces inflammation and prevents insulin resistance and microvascular disease in mice and human macrophages.