Kinetic analysis of ASIC1a delineates conformational signaling from proton sensing domains to the channel gate
Sabrina Vullo, Nicolas Ambrosio, Jan Kučera, Olivier Bignucolo, Stephan Beat Kellenberger
The paper uses voltage-clamp fluorometry and molecular dynamics simulations to analyze the conformational changes in ASIC1a channels during proton activation, showing movement near the gate and distant extracellular sites.
eLife · Mar 17, 2021Peer-reviewedNeuroscience