Jan Kučera

The paper introduces an all-optical Diamond Heater-Thermometer to enable precise thermal modulation of ion channels in living cells.

This study uses computational models to show that low levels of PKP2 gene therapy transduction in ACM patients do not significantly improve conduction velocity but may increase conduction block risk with higher transduction.

The paper uses voltage-clamp fluorometry and molecular dynamics simulations to analyze the conformational changes in ASIC1a channels during proton activation, showing movement near the gate and distant extracellular sites.