Author

Stephan Beat Kellenberger

University of LausanneORCID 0000-0003-1755-6198Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Olivier BignucoloiD· 2 shared Jan KučeraiD· 1 shared Nicolas Ambrosio· 1 shared Ophélie Molton· 1 shared Sabrina VulloiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersNeuroscience

Olivier BignucoloORCID

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2 papers

Recent·Most cited

NeuroscienceOpen BiologyPeer-reviewedJun 1, 2024

Identification of the modulatory Ca2+ binding sites of acid-sensing ion channel 1a

Ophélie Molton, Olivier Bignucolo, Stephan Beat Kellenberger

The paper identifies Ca2+ binding sites in ASIC1a by combining structural data and molecular dynamics simulations, showing how Ca2+ modulates pH-dependent gating.

12 citations

protein structurestatistical model

𝕏 PostBluesky

NeuroscienceeLifePeer-reviewedMar 17, 2021

Kinetic analysis of ASIC1a delineates conformational signaling from proton sensing domains to the channel gate

Sabrina Vullo, Nicolas Ambrosio, Jan Kučera…·Stephan Beat Kellenberger

The paper uses voltage-clamp fluorometry and molecular dynamics simulations to analyze the conformational changes in ASIC1a channels during proton activation, showing movement near the gate and distant extracellular sites.

10 citations

experimental assay

𝕏 PostBluesky