Reciprocal links between methionine metabolism, DNA repair and therapy resistance in glioblastoma
Navyateja Korimerla, Baharan Meghdadi, Isra Haq, Kari Wilder-Romans, Jie Xu, Nicole Becker, Ziqing Zhu, Peter Kalev, Nathan Qi, Charles R. Evans, Maureen T. Kachman, Zitong Zhao, Angelica Lin, Andrew J. Scott, Alexandra M. O’Brien, , Daniel Richard Wahl
This study identifies a metabolic link between methionine metabolism, DNA repair, and radiation resistance in glioblastoma, showing that inhibiting SAM synthesis enhances radiation efficacy.
bioRxiv · Nov 20, 2024 · PreprintCancer Biology