Daniel Richard Wahl

This study shows lactate epigenetically regulates cell states in H3K27M diffuse midline gliomas by modifying histones, and targeting CBP/p300 reduces tumor heterogeneity and improves preclinical outcomes.

This study identifies Abi-1-S323 phosphorylation as a biomarker for DNA repair states and treatment response in cancers, showing its role in regulating radiosensitivity through Rac1 and CHK1 signaling.

This study shows that inhibiting ATM signaling with AZD1390 improves radiation efficacy in H3K27M-altered diffuse midline glioma by enhancing DNA damage repair sensitivity.

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

This study shows that neuronal SEL1L-HRD1 ERAD is critical for one-carbon metabolism, motor function, and survival, with loss leading to severe neurological defects.

This study shows H3K27M diffuse midline glioma is HRR defective and radiosensitized by PARP inhibitors, with enhanced NK cell-mediated immunity.

This study identifies a metabolic link between methionine metabolism, DNA repair, and radiation resistance in glioblastoma, showing that inhibiting SAM synthesis enhances radiation efficacy.

This study identifies SLC4A11 as a mediator of ammonia import in hepatocellular carcinoma, showing its role in promoting cancer stemness and tumor growth.

This study shows that purine metabolism affects DNA repair and therapy resistance in glioblastoma, suggesting that targeting purine synthesis could improve treatment outcomes.