Bicistronic CAR T-cells Against CD70 & Active Integrin β2 Overcome Antigen Heterogeneity and Preserve Safety in Acute Myeloid Leukemia
Amrik S. Kang, H. A. Johnson, Nicole Lei, Jeremiah Wong, Nabeel Razi, Adila Izgutdina, Corynn Kasap, Nikhil Chilakapati, Jose M. Rivera, Paul J. Phojanakong, Juan A. Cámara, Fernando Salangsang, Veronica Steri, Aaron C. Logan, Justin Eyquem, , Arun P. Wiita
This paper develops dual-antigen targeting CAR-T cells against CD70 and active integrin β2 to overcome AML antigen heterogeneity and reduce off-tumor toxicity.
bioRxiv · Sep 21, 2025 · PreprintImmunology