ImmunologybioRxivPreprint
Bicistronic CAR T-cells Against CD70 & Active Integrin β2 Overcome Antigen Heterogeneity and Preserve Safety in Acute Myeloid Leukemia
Amrik S. Kang, H. A. Johnson, Nicole Lei…·Arun P. Wiita
This paper develops dual-antigen targeting CAR-T cells against CD70 and active integrin β2 to overcome AML antigen heterogeneity and reduce off-tumor toxicity.
DOI 10.1101/2025.09.21.677627