Higher-order assembly of a type IX retron enables exploitation for designer antimicrobials
Grace Nicole Hibshman, Linhan Wang, Nicole MacRae, Karen Zhang, Alfredo Jose Florez Ariza, Seth L. Shipman, Eva Nogales
This paper determines the cryo-EM structure of retron-Kva2 and designs synthetic triggers to activate its antimicrobial activity.
bioRxiv · Jul 13, 2026 · PreprintMicrobiology