Alfredo Jose Florez Ariza

This study presents the structure of the human TIP60-C HAT module bound to a nucleosome, revealing how it positions the catalytic center on the nucleosome surface and engages the linker DNA.

This study reports cryo-EM structures of PRC2.1 complexes with different cofactors, revealing how they diversify function while maintaining conserved catalytic mechanisms.

Q208A mutations in up to four subunits of the ClpX central coupler barely slow unfolded-substrate translocation but raise ATP spent per step, weaken force generation and can abolish GFP unfolding.

This paper determines the cryo-EM structure of retron-Kva2 and designs synthetic triggers to activate its antimicrobial activity.

This study determines the structure of the VchCAST holo integration complex using cryo-EM, revealing conformational licensing mechanisms for RNA-guided DNA integration.

This study determines the structure of RECQL5-bound Pol II elongation complexes using cryo-EM, revealing how RECQL5 stabilizes Pol II and modulates its translocation state to reduce transcription stress.