Group B streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model
Sumedha Ravishankar, Samantha M. Tuohey, Nicole O. Ramos, Satoshi Uchiyama, Megan I. Hayes, Kalisa Kang, Victor Nizet, Cressida A. Madigan
This study shows that Group B Streptococcus (GBS) causes meningitis by lysing endothelial cells in zebrafish, not through transcytosis, and identifies inflammation and clotting as key factors in brain invasion.
PLoS Biology · Jul 3, 2025Peer-reviewedMicrobiology