Cressida A. Madigan

This paper uses a zebrafish model of leprosy to identify interferon and plasminogen signaling as critical for survival in mycobacterial infection, using RNAseq and CRISPR screening.

This study shows the mevalonate pathway in Mycobacterium marinum is dispensable in culture but supports metabolic flexibility under stress and during hypoxia.

This study shows that Group B Streptococcus (GBS) causes meningitis by lysing endothelial cells in zebrafish, not through transcytosis, and identifies inflammation and clotting as key factors in brain invasion.

This study uses a zebrafish model to show mycobacteria cause transient vascular occlusions and ischemia during early brain infection, establishing a model for TBM vascular complications.