Amyloid-beta peptides 40 and 42 employ distinct molecular pathways for cell entry and intracellular transit at the BBB endothelium
Zengtao Wang, Nidhi Sharda, Rajesh S. Omtri, Ling Li, Karunya K. Kandimalla
This study identifies distinct endocytic pathways for Aβ40 and Aβ42 in BBB endothelial cells, showing clathrin-mediated uptake for Aβ40 and caveolae-mediated uptake for Aβ42, with differential intracellular trafficking outcomes.
bioRxiv · Nov 17, 2022 · PreprintNeuroscience