Ling Li

Ommochrome pathway knockout via CRISPR/Cas9 reveals sex-linked eye pigmentation and establishes a heritable genome-editing platform in Rhynchophorus ferrugineus

This paper uses CRISPR/Cas9 to knockout genes in the red palm weevil, revealing sex-linked eye pigmentation and establishing a heritable genome-editing platform.

High-density lipoprotein mimetic peptide 4F ameliorates APOE4-associated lipid dysfunction in primary and iPSC-derived astrocytes and cerebral organoids

This study shows that the HDL-mimetic peptide 4F improves APOE secretion and lipidation in E4 astrocytes and organoids, reducing A{beta}42-induced dysfunction.

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

This study shows that macropinocytosis regulates CAF subtype identity under metabolic stress in PDAC, impacting tumor stroma and therapeutic response.

Public RNA-seq data are not representative of global human diversity

The paper analyzes RNA-seq data from public databases and finds significant underrepresentation of non-European populations, highlighting biases in population descriptors.

In Vivo Proximity Labeling Identifies a New Function for the Lifespan and Autophagy-regulating Kinase Pef1, an Ortholog of Human Cdk5

The paper uses proximity labeling to identify Pef1's role in DNA damage response and autophagy-related processes in S. pombe.

Loss of TREM2 exacerbates parenchymal amyloid pathology but diminishes CAA in Tg-SwDI mice

This study shows that TREM2 loss increases parenchymal amyloid-beta but reduces cerebral amyloid angiopathy in Tg-SwDI mice.

Amyloid-beta peptides 40 and 42 employ distinct molecular pathways for cell entry and intracellular transit at the BBB endothelium

This study identifies distinct endocytic pathways for Aβ40 and Aβ42 in BBB endothelial cells, showing clathrin-mediated uptake for Aβ40 and caveolae-mediated uptake for Aβ42, with differential intracellular trafficking outcomes.

CDCP: a visualization and analyzing platform for single-cell datasets

CDCP is a platform for sharing and analyzing single-cell datasets, offering visualization and analysis tools for researchers.

Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice

The paper investigates the role of farnesyltransferase (FT) in Alzheimer's disease by analyzing human brain tissue and generating a mouse model with neuronal FT knockout, finding increased FT and farnesylation in AD and showing mitigation of pathology with FT suppression.

Urine metabolomics of rats with chronic atrophic gastritis

This study identifies 68 differential metabolites in urine of rats with chronic atrophic gastritis using LC-MS, highlighting key metabolic pathways involved.