Combination Treatment with Intravesical Interferon-Alpha Gene Therapy and Oral Pan-ErbB Receptor Family Blocker Improves Survival in Mice with Bladder Cancer
Akshay Sood, Alberto Martini, Paulo Genitiano, Mikael Rauf, Ganiraju C. Manyam, Jan Krzysztof Rudzinski, Côme Tholomier, Roberto Contieri, I.-Ling Lee, Nigel R. Parker, Seppo Yla-Herttuala, David J. McConkey, Colin P N Dinney, Sharada Mokkapati
This paper shows that combining intravesical IFN gene therapy with oral Afatinib improves survival in mice with bladder cancer by targeting the ErbB resistance pathway.
Frontiers in Molecular Biosciences · Aug 10, 2026Peer-reviewedCancer Biology