Spatial polarization of endothelial ICAM-1 governs T-cell exclusion in melanoma
Ha-Ram Park, S. C. Kim, Nika Kozlov, Somnath Tagore, Lawrence Wen Wu, Benjamin Izar, Minah Kim
This study identifies endothelial ICAM-1 as a regulator of T-cell exclusion in melanoma by spatially polarizing its expression, and shows that blocking ICAM-1 enhances T-cell infiltration and immunotherapy efficacy.
bioRxiv · Mar 23, 2026 · PreprintCancer Biology