Ciliopathy interacts with neonatal anesthesia to cause non-apoptotic caspase-mediated motor deficits
Nemanja Sarić, Zeynep Kalender Atak, Courtni Foster Sade, Nikita Reddy, Gabrielle Bell, Christina Tolete, May Rajtboriraks, Kazue Hashimoto‐Torii, Vesna Jevtović‐Todorović, Tarik F. Haydar, Nobuyuki Ishibashi
The paper shows that ciliopathy and neonatal ketamine exposure interact to cause motor deficits through non-apoptotic caspase activation, which can be reversed by caspase inhibition.
bioRxiv · Nov 27, 2024 · PreprintNeuroscience