Tarik F. Haydar

This paper develops a humanized mouse model of prenatal Zika infection and shows it mimics human phenotypes, including disrupted neural stem cells and brain injuries.

The paper introduces a sample multiplexing protocol for simultaneous single nuclei RNA-seq and ATAC-seq, reducing cost and technical batch effects.

The paper shows that ciliopathy and neonatal ketamine exposure interact to cause motor deficits through non-apoptotic caspase activation, which can be reversed by caspase inhibition.

The PING Consortium builds a genomic data repository to study genetic modifiers of prenatal viral infections' effects on brain development and neurodevelopmental outcomes.

This study uses isogenic cortical spheroids and scRNA-seq to identify transcriptomic changes in trisomic cells, revealing developmental asynchrony in excitatory neurons in Down syndrome.

The paper shows that modulating the Sonic Hedgehog pathway in trisomic NPCs rescues gene expression dysregulation associated with Down syndrome.