Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance.
Dale D. O. Martin, Mandi E. Schmidt, Yen Thi-Kim Nguyen, Nikola Lazic, Michael R. Hayden
The paper identifies a new caspase-1 cleavage site in mutant huntingtin that promotes its clearance and reduces aggregation.
The FASEB Journal · Nov 13, 2018Peer-reviewedNeuroscience