Dale D. O. Martin

GAPDH is tethered to axonal transport vesicles by S-acylation

The paper identifies S-acylation of GAPDH on cysteine 247 by ZDHHC5 and ZDHHC17 as essential for its association with axonal transport vesicles.

ZDHHC17 Links S-Acylation, Huntington Disease, VCP-associated Multisystem Proteinopathy, and Amyotrophic Lateral Sclerosis.

This study identifies ZDHHC17 as a key enzyme linking S-acylation to neurodegenerative diseases by modulating protein localization and toxicity.

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program

The paper develops a new S-acylation prediction tool, SAPPTree, by integrating sequence and structural features from experimentally confirmed sites to improve prediction accuracy.

Brain and neuronal expression and localization of de-S-acylating enzymes

The paper characterizes the expression, localization, and S-acylation of cytosolic deacylases in the brain and neurons, identifying their tissue and subcellular distribution.

Vorinostat Rescues SQSTM1 Palmitoylation and Restores Dysfunctional Autophagy in Huntington Disease

Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9

This study identifies ZDHHC9 as a key regulator of oligodendrocyte morphology and myelination, showing its role in palmitoylation of MBP and its impact on XLID.

Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagy

The paper shows reduced S-acylation of SQSTM1/p62 in Huntington disease impairs autophagy by blocking autophagic flux and causing empty autophagosomes.

Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity

This study investigates the role of HTT palmitoylation in Huntington disease by assessing its dysregulation in models and showing that modulating palmitoylation reduces mHTT toxicity.

Identification of novel inhibitors of DLK palmitoylation by High Content Screening

This study identifies novel inhibitors of DLK palmitoylation using high-content screening, finding ketoconazole reduces DLK palmitoylation and c-Jun phosphorylation in neuronal models.

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance.

The paper identifies a new caspase-1 cleavage site in mutant huntingtin that promotes its clearance and reduces aggregation.

A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease

The paper identifies a human SNP that modifies post-translational myristoylation of huntingtin, altering its proteolysis and contributing to Huntington disease pathogenesis.

Feeding Schedule And Proteolysis Regulate Autophagic Clearance Of Mutant Huntingtin

This study shows that scheduled feeding and prevention of caspase-6 cleavage enhance autophagic clearance of mutant huntingtin in HD models and patients.