Author

Yen Thi-Kim Nguyen

University of British ColumbiaORCID 0000-0001-7111-031XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Dale D. O. MartiniD· 2 shared Michael R. HaydeniD· 2 shared Chris KayiD· 1 shared Jennifer A. Collins· 1 shared Mandi E. Schmidt· 1 shared Nikola Lazic· 1 shared R. A. Slama· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersNeuroscience

Dale D. O. MartinORCID

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2 papers

Recent·Most cited

NeuroscienceThe FASEB JournalPeer-reviewedNov 13, 2018

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance.

Dale D. O. Martin, Mandi E. Schmidt, Yen Thi-Kim Nguyen…·Michael R. Hayden

The paper identifies a new caspase-1 cleavage site in mutant huntingtin that promotes its clearance and reduces aggregation.

23 citations

mouseexperimental assay

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GeneticsScientific ReportsPeer-reviewedMay 18, 2018

A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease

Dale D. O. Martin, Chris Kay, Jennifer A. Collins…·Michael R. Hayden

The paper identifies a human SNP that modifies post-translational myristoylation of huntingtin, altering its proteolysis and contributing to Huntington disease pathogenesis.

40 citations

humanproteomics

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