The mutational and clonality profile of HGSOC is established early in tumor development and conserved throughout therapy resistance
Michael Diaz, Nicole Gull, Pei-Chen Peng, Kruttika Dabke, Jessica Baker, Jennifer Sun, Juan Alvarado, Benjamin Bastin, Nimisha Mazumdar, Chintda Santiskulvong, Andrew John Li, Beth Y. Karlan, B.J. Rimel, Sarah J. Parker, Simon A. Gayther, Michelle R. Jones
This study shows that mutational and clonality profiles in HGSOC are established early and remain stable through therapy resistance.
bioRxiv · Feb 14, 2025 · PreprintGenomics