Michael Diaz

The mutational landscape defines the proteome and spatial organization of tumor, stroma and immune cells in ovarian cancer

This study profiles the proteome of ovarian cancer tumors before and after chemotherapy, revealing how HRD status affects immune pathways and identifies potential therapeutic targets.

The mutational and clonality profile of HGSOC is established early in tumor development and conserved throughout therapy resistance

This study shows that mutational and clonality profiles in HGSOC are established early and remain stable through therapy resistance.

Exome sequencing identifies HELB as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer

This study uses exome sequencing to identify HELB as a novel susceptibility gene for non-high grade serous epithelial ovarian cancer, with a strong association found in genetic analyses.