The Colonic Mucus Layer is Thinner and is Associated with Goblet Cell Hyperplasia in the db/db Mouse Model of Type 2 Diabetes
Matthew C. Rowe, Matthias Demuynck, Abhipree Sharma, Cameron J. Nowell, Caitlin Owyong, Nimna Perera, N. Jennifer Tang, Nicholas A. Veldhuis, Pradeep Rajasekhar, Rebecca Helen Ritchie, Miles J. De Blasio, Simona Carbone, Daniel P. Poole
This study examines the impact of diabetes on the colonic mucus layer and goblet cells in db/db mice, finding a thinner mucus layer and goblet cell hyperplasia.
bioRxiv · Apr 6, 2026 · PreprintPhysiology