Nicholas A. Veldhuis

TRPV4 Promotes Histamine Receptor Signaling in Lymphatic Endothelial Cells

This study shows TRPV4 mediates histamine receptor signaling in lymphatic endothelial cells, enhancing Ca2+ signaling and NFATc1 translocation while cytokine release occurs through distinct mechanisms.

The Colonic Mucus Layer is Thinner and is Associated with Goblet Cell Hyperplasia in the db/db Mouse Model of Type 2 Diabetes

This study examines the impact of diabetes on the colonic mucus layer and goblet cells in db/db mice, finding a thinner mucus layer and goblet cell hyperplasia.

Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.

Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons

The paper introduces GAT, a tool for automated analysis of enteric neurons in gut tissue images, improving accuracy and throughput over manual methods.