Cameron J. Nowell

DUSP6 loss enhances dopamine secretion and modulate neurodevelopment in ADHD iPSC-derived dopaminergic neurons

This study investigates the role of DUSP6 in ADHD by generating DUSP6 knockouts in iPSC-derived dopaminergic neurons, finding increased dopamine secretion and transcriptomic changes linked to neurodevelopment and psychiatric disorders.

Unlocking subcellular imaging of a cnidarian photosymbiont Breviolum minutum , through expansion microscopy

This paper develops an expansion microscopy workflow to visualize subcellular features of Breviolum minutum, a cnidarian photosymbiont, overcoming challenges posed by autofluorescence and small size.

The Colonic Mucus Layer is Thinner and is Associated with Goblet Cell Hyperplasia in the db/db Mouse Model of Type 2 Diabetes

This study examines the impact of diabetes on the colonic mucus layer and goblet cells in db/db mice, finding a thinner mucus layer and goblet cell hyperplasia.

Intracellular targeting of a light-activated GPCR elicits spatially selective signalling

This study uses an optogenetic platform to activate a GPCR at different intracellular membranes, showing location-dependent transcriptional responses.

Transcriptome profiling of dopaminergic neurons derived from an ADHD induced pluripotent stem cell (iPSC) model

This study profiles transcriptomes of dopaminergic neurons from ADHD and neurotypical iPSCs, identifying DEGs overlapping with ADHD GWAS results and suggesting delayed neuronal maturation.

Regulation of oogenesis in the queen honey bee (Apis mellifera)

The paper shows honey bee queens use different oogenesis checkpoints than workers but share the same molecular pathways for terminating oocyte development.