Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression
Lindsey C. Osimiri, Alain R. Bonny, Seesha R. Takagishi, Stefanie Luecke, Nina Riehs, Alexander Hoffmann, Hana El‐Samad
The paper uses optogenetic control of RelA to show its nuclear translocation alone can activate downstream genes, revealing dynamic gene responses and the need for complex promoter models.
bioRxiv · Aug 3, 2022 · PreprintSystems Biology