Alain R. Bonny

This study identifies a microbial-immune-epithelial feedback mechanism that regulates stem cell activity and skin barrier function through prostaglandin E2 signaling.

The paper shows E-cadherin redistribution creates tension heterogeneity, triggering cell competition that eliminates pre-malignant cells, but this system can fail, leading to tumor susceptibility.

The paper shows how immune cells adapt to different stem cell niches in skin to maintain tissue homeostasis by adjusting their functions based on the niche's specific demands.

The paper uses optogenetic control of RelA to show its nuclear translocation alone can activate downstream genes, revealing dynamic gene responses and the need for complex promoter models.

The paper introduces TuNR, a synthetic circuit that independently controls mean and variability of gene expression in human cells, enabling study of cell-to-cell heterogeneity.

The paper shows that removing stress-induced cell cycle arrest in yeast accelerates osmotic shock adaptation but increases vulnerability to subsequent stress.

The paper introduces a PDE-constrained optimization framework to estimate cell cycle dynamics from static single-cell data, showing it can identify M-phase arrest in treated K562 cells.

The paper introduces MTK, a toolkit for rapid modular DNA circuit assembly in mammalian cells, demonstrating its use in constructing an Ebola virus replication complex circuit.