DOT1L-AF10-mediated H3K79me3 promotes NF-kB p65-dependent inflammatory activation in endothelial cells
Yash Tushar Katakia, Ritobrata Bhattacharyya, Sushmitha Duddu, Nivedha Suresh, Srinjoy Chakraborty, Nehal Gupta, Suchit Chebolu, Praphulla Chandra Shukla, Syamantak Majumder
This study shows that DOT1L-mediated H3K79me3 promotes NF-κB p65-dependent inflammation in endothelial cells, suggesting it as a therapeutic target for atherogenesis.
bioRxiv · Mar 23, 2026 · PreprintCell Biology