Striatal cell-type-specific molecular signatures reveal therapeutic targets in a model of dystonia
Kaitlyn M. Roman, Ashok Reddy Dinasarapu, Suraj Cherian, Xueliang Fan, Yuping Donsante, Nivetha Aravind, C. Savio Chan, Hyder Azad Jinnah, Ellen J. Hess
The paper identifies cell-type-specific molecular changes in dystonia by analyzing translatomes of dSPNs and iSPNs in DRD mice, revealing glutamatergic signaling disruptions and identifying LRRK2 inhibition as a therapeutic target.
bioRxiv · Oct 7, 2024 · PreprintNeuroscience