C. Savio Chan

The paper identifies cell-type-specific molecular changes in dystonia by analyzing translatomes of dSPNs and iSPNs in DRD mice, revealing glutamatergic signaling disruptions and identifying LRRK2 inhibition as a therapeutic target.

This paper identifies Npas1+ neurons in the basal forebrain as a major GABAergic subpopulation involved in wakefulness and sleep regulation.

The paper characterizes VP Npas1+ neurons' projections, molecular identity, and role in stress response through RNA-seq and chemogenetic manipulation.

This study investigates how pathogenic LRRK2 mutations affect striatal physiology in mice, finding that R1441C causes motor learning deficits rescued by a kinase inhibitor, while G2019S does not.

This study shows that Lmo3 is required for the development of specific GPe neuronal subtypes and their connectivity in the basal ganglia.

This study identifies distinct GPe neuron subtypes using mouse lines and shows their unique roles in motor behavior and anxiety-like behavior through optogenetics and machine learning.

This study identifies that direct-pathway striatal projection neurons (dSPNs) target Npas1+ neurons in the external globus pallidus (GPe) and show that this projection suppresses movement, contributing to Parkinson's disease hypokinesia.

This study identifies distinct roles of PV+ and Npas1+ neurons in the GPe for locomotion and shows differences in their synaptic inputs from the STN in Parkinson's disease.

The paper identifies Npas1+-Nkx2.1+ neurons as a distinct subclass of GPe neurons and describes their role in the cortico-pallido-cortical loop.