Author

Yuping Donsante

Emory UniversityORCID 0000-0002-2000-2973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Ellen J. HessiD· 4 shared Hyder Azad JinnahiD· 4 shared Xueliang Fan· 3 shared Anthony M. Downs· 2 shared Ashok Reddy DinasarapuiD· 2 shared Kaitlyn M. Roman· 2 shared Ahmad Abdal QaderiD· 1 shared C. Savio ChaniD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersNeuroscience

Ellen J. HessORCID

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4 papers

Recent·Most cited

Behavioral Signature of Trihexyphenidyl in The Tor1a (DYT1) Knockin Mouse Model of Dystonia

Ahmad Abdal Qader, Yuping Donsante, Jeffrey E. Markowitz, Hyder Azad Jinnah, Chethan Pandarinath, Ellen J. Hess

The paper uses MoSeq to analyze behavioral changes in dystonia mouse models after trihexyphenidyl treatment, finding genotype and sex-specific shifts in behavioral structure.

Dystonia · Aug 15, 2025Peer-reviewedNeuroscience

Striatal cell-type-specific molecular signatures reveal therapeutic targets in a model of dystonia

Kaitlyn M. Roman, Ashok Reddy Dinasarapu, Suraj Cherian, Xueliang Fan, Yuping Donsante, Nivetha Aravind, C. Savio Chan, Hyder Azad Jinnah, Ellen J. Hess

The paper identifies cell-type-specific molecular changes in dystonia by analyzing translatomes of dSPNs and iSPNs in DRD mice, revealing glutamatergic signaling disruptions and identifying LRRK2 inhibition as a therapeutic target.

bioRxiv · Oct 7, 2024 · PreprintNeuroscience

Cell-intrinsic effects of TorsinA(ΔE) disrupt dopamine release in a mouse model of DYT1-TOR1A dystonia

Anthony M. Downs, Xueliang Fan, Radhika F. Kadakia, Yuping Donsante, Hyder Azad Jinnah, Ellen J. Hess

This study shows that the Tor1a(ΔE) mutation in dopamine neurons reduces dopamine release, while having no effect in cholinergic neurons, indicating a cell-intrinsic role in dystonia.

Neurobiology of Disease · Apr 21, 2021Peer-reviewedNeuroscience

Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders

Maria A. Briscione, Ashok Reddy Dinasarapu, Pritha Bagchi, Yuping Donsante, Kaitlyn M. Roman, Anthony M. Downs, Xueliang Fan, Jessica Hoehner, Hyder Azad Jinnah, Ellen J. Hess

The paper identifies differentially expressed proteins in a mouse model of DOPA-responsive dystonia, revealing shared mechanisms with human dystonic disorders.

bioRxiv · Jan 12, 2021Neuroscience