Performance of polygenic risk scores in screening, prediction, and risk stratification
Aroon Dinesh Hingorani, Jasmine Gratton, Chris Finan, Amand Floriaan Schmidt, Riyaz S. Patel, Reecha Sofat, Valerie Kuan, Claudia Langenberg, Harry Hemingway, Joan K. Morris, NJ Wald
This study evaluates polygenic risk scores for population screening, individual risk prediction, and risk stratification, finding poor performance across all three applications.
medRxiv · Feb 18, 2022 · PreprintGenetic & Genomic Medicine