Harry Hemingway

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

The paper identifies 679 diseases associated with increased risk for severe COVID-19 and Long COVID using UK Biobank health records, highlighting complex multimorbidity patterns and genetic risk loci.

The paper investigates sex differences in the genetic regulation of the plasma proteome and finds most genetic effects are similar between sexes, with few sex-differential effects that do not translate to disease risk.

This study assesses the transferability of genetic loci and polygenic scores for cardiometabolic traits from European-ancestry samples to British Pakistanis and Bangladeshis, finding high transferability for most loci but variable performance for polygenic scores.

This study evaluates polygenic risk scores for population screening, individual risk prediction, and risk stratification, finding poor performance across all three applications.

This study analyzes 70 EHR phenotyping algorithms from CALIBER and UK Biobank to understand their heterogeneity and identify common implementation patterns for developing a minimum information standard.

This paper develops a genomic risk score for coronary artery disease using 1.7 million variants and tests it in UK Biobank, showing it outperforms conventional risk factors in predicting CAD risk.

The paper discusses how integrating druggable target genes with disease susceptibility genes can improve drug development success rates by reducing target specification errors.

The paper estimates the health effects of rare gene knockouts in adults by analyzing exome sequencing data and health records, finding no significant disease associations.