Valerie Kuan

Harnessing confounding and genetic pleiotropy to identify causes of disease through proteomics and Mendelian randomisation - 'MR Fish'.

The paper introduces MR-Fish, a method using proteomics and Mendelian randomisation to identify causal relationships between proteins and diseases, finding causal links for several proteins associated with conditions like T2DM and CHD.

Performance of polygenic risk scores in screening, prediction, and risk stratification

This study evaluates polygenic risk scores for population screening, individual risk prediction, and risk stratification, finding poor performance across all three applications.

Biological mechanisms of aging predict age-related disease multimorbidities in patients

The paper identifies aging mechanisms that predict age-related disease multimorbidities in humans using literature analysis and clinical data integration.

Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

The paper identifies Slit3 as a genetic locus influencing nicotine preference in zebrafish and smoking behavior in humans through mutagenesis screens and SNP analysis.

Flipping the odds of drug development success through human genomics

The paper discusses how integrating druggable target genes with disease susceptibility genes can improve drug development success rates by reducing target specification errors.