Reecha Sofat

The paper introduces MR-Fish, a method using proteomics and Mendelian randomisation to identify causal relationships between proteins and diseases, finding causal links for several proteins associated with conditions like T2DM and CHD.

This study evaluates polygenic risk scores for population screening, individual risk prediction, and risk stratification, finding poor performance across all three applications.

The paper uses Mendelian randomization and clinical/biological evidence to prioritize lipid-modifying drug targets for coronary heart disease prevention.

The paper discusses how integrating druggable target genes with disease susceptibility genes can improve drug development success rates by reducing target specification errors.