Ischemic Injury Drives Tumor Growth via Accelerated Hematopoietic Aging
Alexandra A. C. Newman, José Gabriel Barcia Durán, Richard Von Itter, Jessie M. Dalman, Brian Lim, Morgane Gourvest, Tarik Zahr, Kristin M. Wang, Tracy Zhang, Noah Albarracin, Whitney G. Rubin, Fazli K. Bozal, Michael A. Gildea, Coen V Solingen, Kathryn J. Moore
This study shows that peripheral ischemia accelerates hematopoietic aging, promoting tumor growth by skewing immune cell composition and enhancing immunosuppression.
bioRxiv · May 3, 2025 · PreprintImmunology