Michael A. Gildea

This study shows that peripheral ischemia accelerates hematopoietic aging, promoting tumor growth by skewing immune cell composition and enhancing immunosuppression.

The paper measures in vivo rates of the first and second chemical steps of pre-mRNA splicing across the genome and identifies splice site sequences and ribosomal protein gene features as key determinants of splicing rates.

The paper introduces a targeted RNA-sequencing method using complex primer pools to detect rare splice isoforms with high precision.