The co-evolution of adhesion and F-actin gives rise to hierarchical cellular force generation
Yuanning Guo, Noam Ottolenghi, Malak Amer, Jiayu He, Eran Bouchbinder, Haguy Wolfenson
The paper shows that adhesion assembly, F-actin accumulation, and force generation follow the same time evolution at adhesion sites, with F-actin retrograde flow being faster and not slowing over maturing adhesions.
bioRxiv · Nov 10, 2026 · PreprintCell Biology